Monocytes And Neutrophils Analysis In Pulmonary Tuberculosis Patients At Puskesmas Wonorejo Samarinda

https://doi.org/10.54867/jkm.v12i1.243

Authors

  • Maulida Julia Saputri Poltekkes Kemenkes Banjarmasin
  • Nur Fadilah Poltekkes Kemenkes Kalimantan Timur
  • Rinanda Trianditha Klinik Kumala
  • Titik Srilestari Klinik Utama Alma Medika

Keywords:

Tuberculosis , Monocytes, Neutrophils , Immune Response

Abstract

Tuberculosis (TB) remains a significant global health concern, with the immune response involving key roles for monocytes and neutrophils. Analysis of immune cells, such as monocytes and neutrophils, is crucial for understanding the host response to TB infection and for monitoring treatment effectiveness. This cross-sectional study analyzed the distribution of monocyte and neutrophil counts among 17 pulmonary TB patients in Puskesmas Wonorejo Samarinda from January-April 2024. The collected data were analyzed descriptively. Results showed that 64.70% of patients had elevated monocyte counts, while 35.30% had normal monocyte levels. For neutrophils, 41.20% of patients had normal counts, 17.60% had increased counts, and 41.20% had decreased counts. The predominance of monocyte elevation and the heterogeneous neutrophil response underscore the importance of these cells as potential biomarkers for TB monitoring and prognosis. Strengthening the use of these parameters may improve clinical management and outcomes for TB patients. 

References

Ahor, H. S., Schulte, R., Adankwah, E., Harelimana, J. D. D., Minadzi, D., Acheampong, I., Vivekanandan, M. M., Aniagyei, W., Yeboah, A., Arthur, J. F., Lamptey, M., Abass, M. K., Kumbel, F., Osei-Yeboah, F., Gawusu, A., Debrah, L. B., Owusu, D. O., Debrah, A., Mayatepek, E., … Jacobsen, M. (2023). Monocyte pathology in human tuberculosis is due to plasma milieu changes and aberrant STAT signalling. Immunology, 170(1), 154–166. https://doi.org/10.1111/imm.13659

Brahmbhatt, S. , et al. (2023). Monocyte and neutrophil dynamics during tuberculosis treatment’. Clinical Infectious Diseases.

Buttle, T., & Bothamley, G. (2018). P214 The monocyte to lymphocyte ratio as a biomarker for tuberculosis. Clinical Studies in TB and NTM, A217–A217. https://doi.org/10.1136/thorax-2018-212555.371

Cursi, L., Lancella, L., Mariani, F., Martino, L., Leccese, B., Di Giuseppe, M., Venuti, F., Cristina, R., Gentile, L., Sali, M., Delogu, G., Valentini, P., & Buonsenso, D. (2023). Monocyte‐to‐lymphocyte, neutrophil‐to‐lymphocyte and neutrophil‐to‐monocyte plus lymphocyte ratios in children with active tuberculosis: A multicentre study. Acta Paediatrica, 112(11), 2418–2425. https://doi.org/10.1111/apa.16932

Gatechompol, S., Sophonphan, J., Kerr, S. J., Ubolyam, S., Avihingsanon, A., van Leth, F., & Cobelens, F. (2021). Monocyte-to-lymphocyte ratio as a predictor of TB among people living with HIV. The International Journal of Tuberculosis and Lung Disease, 25(11), 933–938. https://doi.org/10.5588/ijtld.21.0300

Handoko, B., Arliny, Y., Priyanto, H., Andayani, N., & Yanifitri, D. B. (2025). Analysis of Monocyte to Lymphocyte Ratio and Clinical Symptoms of Clinically Confirmed Pulmonary Tuberculosis New Case Patients Before Treatment and After Intensive Phase. Jurnal Respirologi Indonesia, 45(1), 55–60. https://doi.org/10.36497/jri.v45i1.533

Hilda, J. N., Das, S., Tripathy, S. P., & Hanna, L. E. (2020). Role of neutrophils in tuberculosis: A bird’s eye view. In Innate Immunity (Vol. 26, Issue 4, pp. 240–247). SAGE Publications Ltd. https://doi.org/10.1177/1753425919881176

Jeon, Y. La, Lee, W. I., Kang, S. Y., & Kim, M. H. (2019). Neutrophil-to-Monocyte-Plus-Lymphocyte Ratio as a Potential Marker for Discriminating Pulmonary Tuberculosis from Nontuberculosis Infectious Lung Diseases. Lab Medicine, 50(3), 286–291. https://doi.org/10.1093/labmed/lmy083

Kroon, E. E., Correa-Macedo, W., Evans, R., Seeger, A., Engelbrecht, L., Kriel, J. A., Loos, B., Okugbeni, N., Orlova, M., Cassart, P., Kinnear, C. J., Tromp, G. C., Möller, M., Wilkinson, R. J., Coussens, A. K., Schurr, E., & Hoal, E. G. (2023). Neutrophil extracellular trap formation and gene programs distinguish TST/IGRA sensitization outcomes among Mycobacterium tuberculosis exposed persons living with HIV. PLoS Genetics, 19(8 August). https://doi.org/10.1371/journal.pgen.1010888

Leem, A. Y., Song, J. H., Lee, E. H., Lee, H., Sim, B., Kim, S. Y., Chung, K. S., Kim, E. Y., Jung, J. Y., Park, M. S., Kim, Y. S., Chang, J., & Kang, Y. A. (2018). Changes in cytokine responses to TB antigens ESAT-6, CFP-10 and TB 7.7 and inflammatory markers in peripheral blood during therapy. Scientific Reports, 8(1). https://doi.org/10.1038/s41598-018-19523-7

Luo, M., Zou, X., Zeng, Q., Wu, Y., Yang, H., Qin, L., Zheng, R., Yu, F., Hu, Y., & Liu, Z. (2023). Monocyte at diagnosis as a prognosis biomarker in tuberculosis patients with anemia. Frontiers in Medicine, 10. https://doi.org/10.3389/fmed.2023.1141949

Muefong, C. N., & Sutherland, J. S. (2020). Neutrophils in Tuberculosis-Associated Inflammation and Lung Pathology. In Frontiers in Immunology (Vol. 11). Frontiers Media S.A. https://doi.org/10.3389/fimmu.2020.00962

Omair, M., Baig, M. S., Farooqui, W. A., Kousar, S., Noori, M. Y., Zeehan, N., Khan, A., Isa, S., Kamran, D. S., Bari, M. F., & Mehmood, M. (2024). Relationship of neutrophil lymphocyte ratio, monocyte lymphocyte ratio and neutrophil monocyte ratio with treatment response in pulmonary tuberculosis patients during intensive phase treatment. BMC Infectious Diseases, 24(1). https://doi.org/10.1186/s12879-024-09454-2

Rachow, A., Ivanova, O., Wallis, R., Charalambous, S., Jani, I., Bhatt, N., Kampmann, B., Sutherland, J., Ntinginya, N. E., Evans, D., Lönnroth, K., Niemann, S., Schaible, U. E., Geldmacher, C., Sanne, I., Hoelscher, M., & Churchyard, G. (2019). TB sequel: incidence, pathogenesis and risk factors of long-term medical and social sequelae of pulmonary TB – a study protocol. BMC Pulmonary Medicine, 19(1), 1–9. https://doi.org/10.1186/s12890-018-0777-3

Rahman, F. (2024). Characterizing the immune response to Mycobacterium tuberculosis: a comprehensive narrative review and implications in disease relapse. In Frontiers in Immunology (Vol. 15). Frontiers Media SA. https://doi.org/10.3389/fimmu.2024.1437901

Scriba, T. J., Coussens, A. K., & Fletcher, H. A. (2017). Human Immunology of Tuberculosis. Microbiology Spectrum, 5(1). https://doi.org/10.1128/microbiolspec.TBTB2-0016-2016

Sia, J. K., & Rengarajan, J. (2019). Immunology of Mycobacterium tuberculosis Infections . Microbiology Spectrum, 7(4). https://doi.org/10.1128/microbiolspec.gpp3-0022-2018

Suraidah, Irda Handayani, & Nursin Abdul Kadir. (2024). Analysis Neutrophil to Lymphocyte and Monocyte to Lymphocyte Ratios in Pediatric Respiratory Infections Neutrophil to Lymphocyte and Monocyte to Lymphocyte Ratios. 1(1), 38–3. www.indonesianjournalofclinicalpathology.org

The Ministry of Health Republic of Indonesia. (2023). REVISED NATIONAL STRATEGY OF TUBERCULOSIS CARE AND PREVENTION IN INDONESIA 2020-2024 AND INTERIM PLAN FOR 2025-2026.

WHO. (2024). 2024 Global tuberculosis report.

Published

03/30/2025

How to Cite

Julia Saputri, M., Fadilah, N., Trianditha, R., & Srilestari, T. (2025). Monocytes And Neutrophils Analysis In Pulmonary Tuberculosis Patients At Puskesmas Wonorejo Samarinda. Jurnal Kesehatan Mahardika, 12(1), 214–218. https://doi.org/10.54867/jkm.v12i1.243